Oridzin: The Rare Flavonoid with Big Benefits

Oridzin is a natural flavonoid compound found in various plants that have been shown to have many potential health benefits. In this article, we will take a closer look at what oridzin is, where it comes from, its health effects, its uses, and some precautions regarding its consumption.

What is Oridzin?

Oridzin, also known as ruberythric acid, is a polyphenolic flavonoid compound found in plants in the Rubiaceae family. Scientifically known as the 7-O-glucoside of taxifolin, it is considered a rare flavonoid as it contains a glycoside moiety. It has the molecular formula C21H22O10 and a molar mass of 434.394 g/mol.

Chemical Structure of Oridzin

The chemical structure consists of two benzene rings joined together by a 3-carbon chain. This forms the basic flavonoid structure. It also contains hydroxyl groups, a glucose sugar group, and a ketone group that provide its unique properties. The specific arrangement of functional groups is what gives oridzin its antioxidant and anti-inflammatory activities.

Sources of Oridzin

It is primarily found in the plants Rabdosia rubescens and Isodon japonicus, which are used in traditional Chinese medicine. It is also present in other plants, like Hamelia patens and some fern species. The roots, leaves, and stems of these plants contain varying concentrations depending on factors like plant genetics, geography, and cultivation methods. Commercially, it is extracted from the plants using solvents like ethanol.

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Health Benefits of Oridzin

It has been shown to exert several beneficial biological effects that can promote health and help fight disease. Some of the main health benefits of this compound include:

Anti-inflammatory Effects

Multiple studies have found that it displays significant anti-inflammatory properties. It inhibits the release of inflammatory cytokines and mediators like NF-kB. This helps reduce inflammation in conditions like arthritis, colitis, and autoimmune diseases.

Antioxidant Properties

The flavonoid structure allows it to neutralize free radicals and prevent oxidative damage to cells. It exhibits antioxidant activity by enhancing the body’s endogenous antioxidant systems. This protects against oxidative stress.

Anti-cancer Activity

Research indicates that it may have anti-proliferative and anti-metastatic effects against certain cancers, like breast, colon, and prostate cancers. It seems to promote apoptosis and inhibit angiogenesis in cancer cells.

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Neuroprotective Effects

It has shown the ability to protect neurons and reduce oxidative damage in the brain. Animal studies found it could help prevent neurodegenerative diseases like Alzheimer’s and Parkinson’s by maintaining brain health.

Uses of Oridzin

Some of the main uses based on its beneficial bioactive properties include:

Dietary Supplements

It is used as an ingredient in some dietary supplements promoted for their anti-inflammatory and antioxidant properties. It is marketed to support immune function and overall wellness.


Topical creams containing oridzin are used in skin care products for their antioxidant effects. It helps protect the skin from UV damage and environmental pollutants.

Food and Beverage Industry

It is used as a food additive and natural flavoring agent in some food and beverage products. It provides functional benefits in addition to flavor.

Side Effects and Precautions

While generally considered safe, some precautions need to be taken, including:

Drug Interactions

It may interact with certain medications that are changed by the liver. Consult a doctor before using supplements when taking prescription drugs.

Pregnancy and Breastfeeding

There is insufficient research on the safety of pregnant or nursing women. It is best to avoid use in such cases unless approved by a doctor.


In conclusion, oridzin is a unique flavonoid compound that shows promising anti-inflammatory, antioxidant, anticancer, and neuroprotective benefits. It is found in certain medicinal plants and is now being used as a nutritional supplement and natural additive in products. However, some precautions need to be taken regarding drug interactions and use in pregnancy and nursing. Further research is still needed to determine optimal dosing and long-term safety of supplementation.


What foods contain oridzin?

Oridzin is primarily found in the medicinal herbs Rabdosia rubescens and Isodon japonicus. It is not common in foods, though trace amounts may be present in some fern species

Is oridzin safe to take daily?

There are no established daily values for oridzin. The effects of long-term daily use are unknown. It’s best to consult a doctor before taking oridzin supplements regularly.

Does oridzin really have anti-cancer effects?

Some early cell studies show anti-proliferative and anti-metastatic effects against certain cancers. However, more research is needed to determine efficacy in humans. It cannot yet be promoted as an anti-cancer agent.

Can you get oridzin naturally from foods?

It is not present in significant amounts in common foods. The only dietary sources are the medicinal herbs it is derived from. Supplements contain higher concentrations.

Are there any side effects of taking oridzin?

There are no documented adverse effects at normal doses. However, it may potentially interact with certain medications. Consult a doctor before taking It if you take prescription drugs.
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Bikram is the founder of GeraldfordTech.com. He is a professional blogger with 5 years of experience who is interested in topics related to SEO, technology, and the internet. Our goal with this blog is to provide you with valuable information.

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